Atrial Natriuretic Peptide Attenuates Agonist Induced Pulmonary Edema In Mice
نویسندگان
چکیده
Address correspondence to: 13 James R. Klinger 14 Division of Pulmonary, 15 Sleep and Critical Care Medicine 16 Rhode Island Hospital 17 593 Eddy Street 18 Providence, RI 02903 19 Phone: 401-444-2776 20 Fax: 401-444-3002 21 Email: [email protected] 22 23 Subject codes: 24 [18] Pulmonary circulation and disease 25 [95] Endothelium/vascular type/nitric oxide 26 [130] Animal models of human disease 27 [138] Cell signaling/signal transduction 28 [145] Genetically altered mice 29 30 Running title: ANP and pulmonary edema in NPR-A-/mice 31 32 Articles in PresS. J Appl Physiol (November 29, 2012). doi:10.1152/japplphysiol.01249.2011
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Atrial natriuretic peptide attenuates agonist-induced pulmonary edema in mice with targeted disruption of the gene for natriuretic peptide receptor-A.
Atrial natriuretic peptide (ANP) inhibits agonist-induced pulmonary edema formation, but the signaling pathway responsible is not well defined. To investigate the role of the particulate guanylate cyclase-linked receptor, natriuretic peptide receptor-A (NPR-A), we measured acute lung injury responses in intact mice and pulmonary microvascular endothelial cells (PMVEC) with normal and disrupted ...
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1 De Bold AJ, Borenstein HB, Veress AT, et al. A rapid and potent natriuretic response to intravenous injection of atrial myocardial extracts in rats. Life Sci 1981; 28:89-94 2 Adnot S, Chabrier PE, Brun-Buisson C, et al. Atrial natriuretic factor attenuates the pulmonary pressor response to hypoxia. J Appl Physiol 1988; 65:1975-88 3 McKenzie JC, Tanaka I, Inagami T, et al. Alterations in atria...
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